If not enough glutathione is being produced relative to the oxidative or free radical load present, then the free radicals, seeking balance, will rip holes in the neighboring cells and neuroinflammation will occur
Endocrinology 144, 51845187
Nutrition Facts Serving Size: 1 Softgel Servings Per Container: 120 Milk Thistle Extract (Silybum marianum) (fruit/seed) (standardized to 360 mg silymarin flavonoids - 80% equivalent) 450 mg Softgel capsule [bovine gelatin (BSE-free), glycerin, water, organic caramel color], organic sunflower oil, sunflower lecithin and silicon dioxide
Other notable side effects included fatigue, joint pain, hair loss, and headaches, particularly with drugs such as tirzepatide
Interestingly, the gut-brain-kidney axis has significant implications for the development and progression of CKD, offering options for the management and treatment of the condition